Irene Geninatti Chiolero started out on her artistic path in the mid 1990s as a theatre actress and in 2000 she graduated from the Kuniaki Ida School of Dramatic Arts in Milan. In that same year she began to study operatic signing, with advanced tuition under the guidance of Anatoli Gussev.

In 2005 she won first prize at the International Competition for Young Opera Singers in Monte Corvino Rovella, and was also a finalist in the Opera Competition "Luciano Neroni" in Ripatransone. In 2006 she won the prize “Mattia Battistini” in the 12th International Competition for Opera Singers in Rieti, and got to the final of the international competition in Rijeka (Croatia). From 2008-12 she worked with the Italian Operetta Company.

She works regularly with the orchestra Alessandro Volta and its principal conductor Meastro Alessandro Bares, with whom she founded the Opera Company of Milan in 2009, which produces operatic and symphonic events.

In 2010, Irene founded the cultural association “Masca in Langa”. With this association she organises the Popular Festival of Culture in the area of Valle Bormida (in Piemonte, Italy) encouraging its development with cultural and artistic activities. In that year she also founded the "Orchestra Sinfonica Giovanile Aleramica”, to help young classical musicians enter the world of work.

In September 2011 she was amongst those involved in the huge cerimony to celebrate the opening of the new Juventus football stadium in Turin, in which she sang the celebrated aria "Un bel dì vedremo.." from Madam Butterfly by Puccini - an aria shown all around the world by Sky and other national and international TV channels.